This is an actual patient story, but the patient’s name has been changed and a stock photo has been used to protect her privacy.

Getting the right diagnosis changed my life.

– Mary
a person living with NAGS deficiency

READ MARY'S STORY

Any episode of acute hyperammonemia should be treated as a life-threatening emergency

People with NAGS deficiency, Propionic Acidemia or Methylmalonic Acidemia may experience acute high blood ammonia levels. At high levels, ammonia is toxic (or poisonous), especially to the brain. Lowering high blood ammonia levels quickly is key.

High blood ammonia levels can occur for many years before diagnosis

Some people have episodes of high blood ammonia for many years before being properly diagnosed and treated. This happened to Mary, who was eventually diagnosed with NAGS deficiency.

READ HER STORY

This is an actual patient story, but the patient’s name has been changed and a stock photo has been used to protect her privacy.

Getting the right diagnosis changed my life.

– Mary
a person living with NAGS deficiency

READ MARY'S STORY

UNDERSTANDING PA, MMA, AND NAGS DEFICIENCY

PA, MMA, and NAGS deficiency are rare, inherited metabolic disorders that can cause high blood ammonia levels. High ammonia levels can be extremely toxic to the brain in infants, children, and adults and should be treated as a life-threatening emergency.

Understanding PA and MMA Understanding NAGS deficiency

IT'S ABOUT TIME

to learn how CARBAGLU can help lower ammonia levels in people with PA, MMA, or NAGS deficiency.

Taking CARBAGLU

It’s important to take CARBAGLU exactly as prescribed by your doctor
LEARN HOW TO TAKE CARBAGLU
Patient Support

Get access to financial and other support for CARBAGLU
ACCESS CARBAGLU RESOURCES
Getting CARBAGLU

Your prescription can be delivered right to your home
LEARN MORE ABOUT HOME DELIVERY FOR NAGS DEFICIENCY PATIENTS

INDICATIONS AND USAGE

Carbaglu^® (carglumic acid) tablets for oral suspension 200mg is a prescription drug used in all ages to help treat the following:

CARBAGLU is used to supplement standard of care treatment for acute high blood ammonia levels (hyperammonemia) due to the lack or shortage of NAGS enzyme activity.
CARBAGLU is used to maintain normal blood ammonia levels due to the lack or shortage of NAGS enzyme activity.
CARBAGLU is used to supplement standard of care treatment for acute high blood ammonia levels due to propionic acidemia (PA) or methylmalonic acidemia (MMA).

IMPORTANT SAFETY INFORMATION

Contraindications: None.
NAGS deficiency: Most common side effects in ≥13% of patients are: vomiting, abdominal pain, fever, inflammation of the tonsils, reduced red cells in the blood, diarrhea, ear infection, infections, inflammation of the throat and nasal passages, hemoglobin decreased in red blood cells, and headache.
PA and MMA: Most common side effects in ≥5% of patients are: lower than normal white blood cells, reduced red cells in the blood, vomiting, abnormal levels of minerals in the body, decreased appetite, low blood sugar levels, lack of energy/unresponsiveness, brain disease that alters brain structure or function, and inflammation of the pancreas/increase in a type of protein made by the pancreas that helps the body digest fats.

To report SUSPECTED SIDE EFFECTS, contact Recordati Rare Diseases Inc. at 1-888-575-8344, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

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Any episode of acute hyperammonemia should be treated as a life-threatening emergency

High blood ammonia levels can occur for many years before diagnosis

UNDERSTANDING PA, MMA, AND NAGS DEFICIENCY

IT'S ABOUT TIME

Taking CARBAGLU

Patient Support

Getting CARBAGLU

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION